2DYH

Crystal structure of the Keap1 protein in complexed with the N-terminal region of the Nrf2 transcription factor

Summary for 2DYH

Entry DOI	10.2210/pdb2dyh/pdb
Related	1X2J 1X2R
Descriptor	Kelch-like ECH-associated protein 1, Nrf2/Neh2 peptide from Nuclear factor erythroid 2-related factor 2, SULFATE ION, ... (4 entities in total)
Functional Keywords	bet-propeller, kelch motif, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
Biological source	Mus musculus (mouse) More
Cellular location	Cytoplasm: Q9Z2X8 Cytoplasm, cytosol: Q60795
Total number of polymer chains	2
Total formula weight	37479.77
Authors	Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-09-14, release date: 2007-09-04, Last modification date: 2023-10-25)
Primary citation	Tong, K.I.,Padmanabhan, B.,Kobayashi, A.,Shang, C.,Hirotsu, Y.,Yokoyama, S.,Yamamoto, M. Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response Mol.Cell.Biol., 27:7511-7521, 2007 Cited by PubMed: 17785452 DOI: 10.1128/MCB.00753-07 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation