2D82

Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association

Summary for 2D82

• Entry DOI: 10.2210/pdb2d82/pdb
• Related: 1jsp
• NMR Information: BMRB: 6960
• Descriptor: CREB-binding protein, 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE (2 entities in total)
• Functional Keywords: bromodomain, creb, cbp, p53, chemical ligand, 9-acetyl-2, 3, 4, 9-tetrahydro-carbazol-1-one, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 1
• Total formula weight: 14645.81

Authors

Sachchidanand,Resnick-Silverman, L.,Yan, S.,Mujtaba, S.,Liu, W.J.,Zeng, L.,Manfredi, J.J.,Zhou, M.M. (deposition date: 2005-12-01, release date: 2006-04-04, Last modification date: 2022-03-09)

• Primary citation: Sachchidanand,Resnick-Silverman, L.,Yan, S.,Mutjaba, S.,Liu, W.J.,Zeng, L.,Manfredi, J.J.,Zhou, M.M.; Target structure-based discovery of small molecules that block human p53 and CREB binding protein association; Chem.Biol., 13:81-90, 2006; PubMed: 16426974; DOI: 10.1016/j.chembiol.2005.10.014

Experimental method

SOLUTION NMR