2D26

Active site distortion is sufficient for proteinase inhibit second crystal structure of covalent serpin-proteinase complex

Summary for 2D26

Entry DOI	10.2210/pdb2d26/pdb
Descriptor	Alpha-1-antitrypsin, Elastase-1, ... (4 entities in total)
Functional Keywords	serpine proteinase, serpin, covalent serpin-proteinase comp protein-protein interactions, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009 P01009 Secreted: P00772
Total number of polymer chains	3
Total formula weight	70178.27
Authors	Dementiev, A.,Dobo, J.,Gettins, P.G. (deposition date: 2005-09-03, release date: 2005-11-29, Last modification date: 2023-10-25)
Primary citation	Dementiev, A.,Dobo, J.,Gettins, P.G. Active Site Distortion Is Sufficient for Proteinase Inhibition by Serpins: Structure of the covalent complex of alpha 1-proteinase inhibitor with porcine pancreatic elastase J.Biol.Chem., 281:3452-3457, 2006 Cited by PubMed: 16321984 DOI: 10.1074/jbc.M510564200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation