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2CN5

Crystal structure of human Chk2 in complex with ADP

Summary for 2CN5
Entry DOI10.2210/pdb2cn5/pdb
Related1GXC 2CN8
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK2, CHLORIDE ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordstransferase, kinase, kinase domain, checkpoint, cancer, tumour suppressor, chek2, chk2, cds1, rad53, phosphorylation, activation segment, li-fraumeni syndrome, atp-binding, cell cycle, disease mutation, magnesium, metal-binding, nuclear protein, nucleotide-binding, proto-oncogene, serine/threonine-protein kinase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains1
Total formula weight37685.11
Authors
Oliver, A.W.,Pearl, L.H. (deposition date: 2006-05-18, release date: 2006-06-28, Last modification date: 2023-12-13)
Primary citationOliver, A.W.,Paul, A.,Boxall, K.J.,Barrie, S.E.,Aherne, G.W.,Garrett, M.D.,Mittnacht, S.,Pearl, L.H.
Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Embo J., 25:3179-, 2006
Cited by
PubMed: 16794575
DOI: 10.1038/SJ.EMBOJ.7601209
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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