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2CF9

Complex of recombinant human thrombin with an inhibitor

Summary for 2CF9
Entry DOI10.2210/pdb2cf9/pdb
Related2CF8
Related PRD IDPRD_000481
DescriptorTHROMBIN HEAVY CHAIN, HIRUDIN IIIA, THROMBIN LIGHT CHAIN, ... (7 entities in total)
Functional Keywordshydrolase/inhibitor, acute phase, blood coagulation, calcium-binding, glycoprotein, hydolase, serine protease, serine protease inhibitor complex, complex hydrolase-inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28508
Total number of polymer chains3
Total formula weight34803.87
Authors
Schweizer, E.,Hoffmann-Roeder, A.,Olsen, J.A.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. (deposition date: 2006-02-17, release date: 2006-06-14, Last modification date: 2023-12-13)
Primary citationSchweizer, E.,Hoffmann-Roeder, A.,Olsen, J.A.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F.
Multipolar Interactions in the D Pocket of Thrombin: Large Differences between Tricyclic Imide and Lactam Inhibitors.
Org.Biomol.Chem., 4:2364-, 2006
Cited by
PubMed: 16763681
DOI: 10.1039/B602585D
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.79 Å)
Structure validation

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