2C67

MAO inhibition by rasagiline analogues

Summary for 2C67

Entry DOI	10.2210/pdb2c67/pdb
Related	1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66
Descriptor	AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, N-METHYL-1(R)-AMINOINDAN, ... (4 entities in total)
Functional Keywords	oxidoreductase, enantioselectivity, fad, flavin, flavoprotein, human monoamine oxidase, inhibitor binding, mitochondrion, rasagiline, transmembrane, parkinson
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains	2
Total formula weight	119540.99
Authors	Binda, C.,Hubalek, F.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A. (deposition date: 2005-11-07, release date: 2006-01-04, Last modification date: 2023-12-13)
Primary citation	Binda, C.,Hubalek, F.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A. Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis. J.Med.Chem., 48:8148-, 2005 Cited by PubMed: 16366596 DOI: 10.1021/JM0506266 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation