2C64

MAO inhibition by rasagiline analogues

Summary for 2C64

Entry DOI	10.2210/pdb2c64/pdb
Related	1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C65 2C66 2C67
Descriptor	AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, (1R)-6-HYDROXY-N-METHYL-N-[(1Z)-PROP-2-EN-1-YLIDENE]INDAN-1-AMINIUM, ... (4 entities in total)
Functional Keywords	oxidoreductase, acetylation, enantioselectivity, fad, flavin, flavoprotein, human monoamine oxidase, inhibitor binding, mitochondrion, rasagiline, transmembrane
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains	2
Total formula weight	119448.83
Authors	Binda, C.,Hubalek, F.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A. (deposition date: 2005-11-07, release date: 2006-01-04, Last modification date: 2011-07-13)
Primary citation	Binda, C.,Hubalek, F.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A. Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis. J.Med.Chem., 48:8148-, 2005 Cited by PubMed: 16366596 DOI: 10.1021/JM0506266 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation