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2C3I

CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I

Summary for 2C3I
Entry DOI10.2210/pdb2c3i/pdb
Related1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK
DescriptorPIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ... (4 entities in total)
Functional Keywordstransferase-peptide complex, complex transferase-peptide, pim1, kinase, cancer, leukemia, atp-binding, nuclear protein, nucleotide-binding, phosphorylation, proto- oncogene, serine/threonine-protein kinase, transferase, transferase/peptide
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains2
Total formula weight36937.13
Authors
Philippakopoulos, P.,Knapp, S.,Debreczeni, J.,Bullock, A.,von Delft, F.,Sundstrom, M.,Arrowsmith, C.,Edwards, A.,Guo, K.,Weigelt, J. (deposition date: 2005-10-07, release date: 2005-11-01, Last modification date: 2023-12-13)
Primary citationPogacic, V.,Bullock, A.N.,Fedorov, O.,Filippakopoulos, P.,Gasser, C.,Biondi, A.,Meyer-Monard, S.,Knapp, S.,Schwaller, J.
Structural Analysis Identifies Imidazo[1,2- B]Pyridazines as Pim Kinase Inhibitors with in Vitro Antileukemic Activity.
Cancer Res., 67:6916-, 2007
Cited by
PubMed: 17638903
DOI: 10.1158/0008-5472.CAN-07-0320
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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