2BZS

Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.

Summary for 2BZS

Entry DOI	10.2210/pdb2bzs/pdb
Related	1QR2 1SG0 1ZX1 2QR2
Descriptor	NRH DEHYDROGENASE [QUINONE] 2, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	oxidoreductase, nqo2, cb1954, fad, flavoprotein, metal-binding, polymorphism, zinc
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	55126.38
Authors	Abu Khader, M.M.,Heap, J.T.,De Matteis, C.,Kellam, B.,Doughty, S.W.,Minton, N.,Paoli, M. (deposition date: 2005-08-22, release date: 2005-09-23, Last modification date: 2023-12-13)
Primary citation	Abu Khader, M.M.,Heap, J.T.,De Matteis, C.,Kellam, B.,Doughty, S.W.,Minton, N.,Paoli, M. Binding of the Anticancer Prodrug Cb1954 to the Activating Enzyme Nqo2 Revealed by the Crystal Structure of Their Complex. J.Med.Chem., 48:7714-, 2005 Cited by PubMed: 16302811 DOI: 10.1021/JM050730N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation