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2B8W

Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP/AlF4

Summary for 2B8W
Entry DOI10.2210/pdb2b8w/pdb
Related1DG3 1F5N 2B92 2BC9 2D4H
DescriptorInterferon-induced guanylate-binding protein 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION, ... (5 entities in total)
Functional Keywordsprotein- guanine nucleotide complex, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P32455
Total number of polymer chains2
Total formula weight75137.90
Authors
Ghosh, A.,Praefcke, G.J.K.,Renault, L.,Wittinghofer, A.,Herrmann, C. (deposition date: 2005-10-10, release date: 2006-03-07, Last modification date: 2023-08-23)
Primary citationGhosh, A.,Praefcke, G.J.,Renault, L.,Wittinghofer, A.,Herrmann, C.
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Nature, 440:101-104, 2006
Cited by
PubMed: 16511497
DOI: 10.1038/nature04510
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.22 Å)
Structure validation

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