2B7D

Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model

Summary for 2B7D

Entry DOI	10.2210/pdb2b7d/pdb
Descriptor	Coagulation factor VII, Tissue factor, (2R)-2-[5-(5-CARBAMIMIDOYL-1H-BENZOIMIDAZOL-2-YL)-6,2'-DIHYDROXY-5'-UREIDOMETHYL-BIPHENYL-3-YL]-SUCCINIC ACID, ... (5 entities in total)
Functional Keywords	short hydrogen bond, blood clotting
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P08709 P08709 Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
Total number of polymer chains	3
Total formula weight	70422.17
Authors	Young, W.B.,Mordenti, J.,Torkelson, S.,Shrader, W.D.,Kolesnikov, A.,Rai, R.,Liu, L.,Hu, H.,Leahy, E.M.,Green, M.J.,Sprengeler, P.A.,Katz, B.A.,Yu, C.,Janc, J.W.,Elrod, K.C.,Marzec, U.M.,Hanson, S.R. (deposition date: 2005-10-04, release date: 2006-02-14, Last modification date: 2023-08-23)
Primary citation	Young, W.B.,Mordenti, J.,Torkelson, S.,Shrader, W.D.,Kolesnikov, A.,Rai, R.,Liu, L.,Hu, H.,Leahy, E.M.,Green, M.J.,Sprengeler, P.A.,Katz, B.A.,Yu, C.,Janc, J.W.,Elrod, K.C.,Marzec, U.M.,Hanson, S.R. Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. Bioorg.Med.Chem.Lett., 16:2037-2041, 2006 Cited by PubMed: 16412633 DOI: 10.1016/j.bmcl.2005.12.059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation