2B52

Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562

Summary for 2B52

Entry DOI	10.2210/pdb2b52/pdb
Related	2B53 2B54 2B55
Descriptor	Cell division protein kinase 2, 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA (3 entities in total)
Functional Keywords	protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34414.01
Authors	Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2024-02-14)
Primary citation	Yue, E.W.,Dimeo, S.V.,Higley, C.A.,Markwalder, J.A.,Burton, C.R.,Benfield, P.A.,Grafstrom, R.H.,Cox, S.,Muckelbauer, J.K.,Smallwood, A.,Chen, H.,Chang, C.-H.,Trainor, G.L.,Seitz, S.P. Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. Part 4: Heterocycles at C3 Bioorg.Med.Chem.Lett., 14:343-346, 2004 Cited by PubMed: 14698155 DOI: 10.1016/j.bmcl.2003.11.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation