2AYL

2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen

2AYL の概要

• エントリーDOI: 10.2210/pdb2ayl/pdb
• 関連するPDBエントリー: 1EQG 1EQH 1HT5 1HT8 1PRH 1Q4G
• 分子名称: Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: cyclooxygenase, non-steroidal anti-inflammatory drug, peroxidase, prostaglandin synthase, egf-like domain, membrane binding domain, maganese protoporphyrin ix, oxidoreductase
• 由来する生物種: Ovis aries (sheep)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 135842.83

構造登録者

Gupta, K.,Selinsky, B.S.,Loll, P.J. (登録日: 2005-09-07, 公開日: 2006-01-24, 最終更新日: 2023-08-23)

• 主引用文献: Gupta, K.,Selinsky, B.S.,Loll, P.J.; 2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor.; Acta Crystallogr.,Sect.D, 62:151-156, 2006; PubMed: 16421446; DOI: 10.1107/S0907444905036309

実験手法

X-RAY DIFFRACTION (2 Å)