2AXN

Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Summary for 2AXN

Entry DOI	10.2210/pdb2axn/pdb
Descriptor	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)], 6-O-phosphono-beta-D-fructofuranose, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID, ... (5 entities in total)
Functional Keywords	bifunctional enzyme, edta complex, transferase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	60673.72
Authors	Kim, S.G.,Manes, N.P.,El-Maghrabi, M.R.,Lee, Y.H. (deposition date: 2005-09-05, release date: 2005-12-06, Last modification date: 2023-08-23)
Primary citation	Kim, S.G.,Manes, N.P.,El-Maghrabi, M.R.,Lee, Y.H. Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. J.Biol.Chem., 281:2939-2944, 2006 Cited by PubMed: 16316985 DOI: 10.1074/jbc.M511019200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation