2AXG

The Immunogenicity of a Viral Cytotoxic T Cell Epitope is controlled by its MHC-bound Conformation

Summary for 2AXG

Entry DOI	10.2210/pdb2axg/pdb
Related	2AXF
Descriptor	HLA class I histocompatibility antigen, B*3501 heavy chain, Beta-2-microglobulin, 10-mer peptide from BZLF1 trans-activator protein, ... (5 entities in total)
Functional Keywords	immune response, pmhc, immune system-gene regulation complex, immune system/gene regulation
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P30685 Secreted . Note=(Microbial infection) In the presence of M: P61769 Host nucleus : P03206
Total number of polymer chains	3
Total formula weight	44865.62
Authors	Tynan, F.E.,Elhassen, D.,Purcell, A.W.,Burrows, J.M.,Borg, N.A.,Miles, J.J.,Williamson, N.A.,Green, K.J.,Tellam, J.,Kjer-Nielsen, L.,McCluskey, J.,Rossjohn, J.,Burrows, S.R. (deposition date: 2005-09-05, release date: 2005-11-29, Last modification date: 2017-10-11)
Primary citation	Tynan, F.E.,Elhassen, D.,Purcell, A.W.,Burrows, J.M.,Borg, N.A.,Miles, J.J.,Williamson, N.A.,Green, K.J.,Tellam, J.,Kjer-Nielsen, L.,McCluskey, J.,Rossjohn, J.,Burrows, S.R. The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation J.Exp.Med., 202:1249-1260, 2005 Cited by PubMed: 16275762 DOI: 10.1084/jem.20050864 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation