2AX0

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)

2AX0 の概要

• エントリーDOI: 10.2210/pdb2ax0/pdb
• 分子名称: Genome polyprotein, SULFATE ION, 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, ... (4 entities in total)
• 機能のキーワード: hcv, ns5b, polymerase, fingers, thumb, palm, transferase
• 由来する生物種: Hepatitis C virus
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 130785.68

構造登録者

Powers, J.P.,Piper, D.E.,Li, Y.,Mayorga, V.,Anzola, J.,Chen, J.M.,Jaen, J.C.,Lee, G.,Liu, J.,Peterson, M.G.,Tonn, G.R.,Ye, Q.,Walker, N.P.,Wang, Z. (登録日: 2005-09-02, 公開日: 2006-01-24, 最終更新日: 2021-10-20)

• 主引用文献: Powers, J.P.,Piper, D.E.,Li, Y.,Mayorga, V.,Anzola, J.,Chen, J.M.,Jaen, J.C.,Lee, G.,Liu, J.,Peterson, M.G.,Tonn, G.R.,Ye, Q.,Walker, N.P.,Wang, Z.; SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase.; J.Med.Chem., 49:1034-1046, 2006; PubMed: 16451069; DOI: 10.1021/jm050859x

実験手法

X-RAY DIFFRACTION (2 Å)