2AW1

Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib

Summary for 2AW1

Entry DOI	10.2210/pdb2aw1/pdb
Related	1CA2 1OQ5
Descriptor	Carbonic anhydrase II, ZINC ION, 4-(HYDROXYMERCURY)BENZOIC ACID, ... (6 entities in total)
Functional Keywords	carbonic anhydrase, protein-inhibitor complex, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30060.53
Authors	Di Fiore, A.,Pedone, C.,D'Ambrosio, K.,Scozzafava, A.,De Simone, G.,Supuran, C.T. (deposition date: 2005-08-31, release date: 2006-07-04, Last modification date: 2023-10-25)
Primary citation	Di Fiore, A.,Pedone, C.,D'Ambrosio, K.,Scozzafava, A.,De Simone, G.,Supuran, C.T. Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II Bioorg.Med.Chem.Lett., 16:437-442, 2006 Cited by PubMed: 16290146 DOI: 10.1016/j.bmcl.2005.09.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation