2AST

Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide

Summary for 2AST

• Entry DOI: 10.2210/pdb2ast/pdb
• Related: 1FQV 2ASS
• Descriptor: S-phase kinase-associated protein 1A, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ... (6 entities in total)
• Functional Keywords: scf-substrate complex, lrr, cell cycle, protein turnover complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P46527
• Total number of polymer chains: 4
• Total formula weight: 65908.13

Authors

Hao, B.,Zhang, N.,Schulman, B.A.,Wu, G.,Pagano, M.,Pavletich, N.P. (deposition date: 2005-08-24, release date: 2005-10-18, Last modification date: 2023-08-23)

• Primary citation: Hao, B.,Zheng, N.,Schulman, B.A.,Wu, G.,Miller, J.J.,Pagano, M.,Pavletich, N.P.; Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.; Mol.Cell, 20:9-19, 2005; PubMed: 16209941; DOI: 10.1016/j.molcel.2005.09.003

Experimental method

X-RAY DIFFRACTION (2.3 Å)