2AMB

Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone

2AMB の概要

• エントリーDOI: 10.2210/pdb2amb/pdb
• 関連するPDBエントリー: 2AM9 2AMA
• 分子名称: Androgen receptor, SULFATE ION, 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE, ... (7 entities in total)
• 機能のキーワード: nuclear receptor, androgen receptor, ligand binding domain, thg, agonist, designer androgen, hormone-growth factor receptor complex, hormone/growth factor receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31889.35

構造登録者

Pereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R. (登録日: 2005-08-09, 公開日: 2006-05-16, 最終更新日: 2023-08-23)

• 主引用文献: Pereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R.; Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.; Protein Sci., 15:987-999, 2006; PubMed: 16641486; DOI: 10.1110/ps.051905906

実験手法

X-RAY DIFFRACTION (1.75 Å)