2AJ9

X-ray crystal structure of W42A,R161A double mutant of Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III

Summary for 2AJ9

• Entry DOI: 10.2210/pdb2aj9/pdb
• Related: 1m1m
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase III (2 entities in total)
• Functional Keywords: beta-ketoacyl-acp synthase iii, 3-oxoacyl-acp synthase iii, mtfabh, fabh, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 73875.25

Authors

Brown, A.K.,Sridharan, S.,Kremer, L.,Lindenberg, S.,Dover, L.G.,Sacchettini, J.C.,Besra, G.S. (deposition date: 2005-08-01, release date: 2005-08-30, Last modification date: 2023-08-23)

• Primary citation: Brown, A.K.,Sridharan, S.,Kremer, L.,Lindenberg, S.,Dover, L.G.,Sacchettini, J.C.,Besra, G.S.; Probing the Mechanism of the Mycobacterium tuberculosis beta-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: Factors Influencing Catalysis And Substrate Specificity.; J.Biol.Chem., 280:32539-32547, 2005; PubMed: 16040614; DOI: 10.1074/jbc.M413216200

Experimental method

X-RAY DIFFRACTION (2.5 Å)