2AF0

Structure of the Regulator of G-Protein Signaling Domain of RGS2

Summary for 2AF0

Entry DOI	10.2210/pdb2af0/pdb
Descriptor	Regulator of G-protein signaling 2 (2 entities in total)
Functional Keywords	helix, structural genomics, structural genomics consortium, sgc, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Cell membrane. Isoform 2: Cell membrane. Isoform 3: Cell membrane. Isoform 4: Cell membrane: P41220
Total number of polymer chains	1
Total formula weight	16994.15
Authors	Papagrigoriou, E.,Johannson, C.,Phillips, C.,Smee, C.,Elkins, J.M.,Weigelt, J.,Arrowsmith, C.,Edwards, A.,Sundstrom, M.,Von Delft, F.,Doyle, D.A.,Structural Genomics Consortium (SGC) (deposition date: 2005-07-25, release date: 2005-08-02, Last modification date: 2024-03-13)
Primary citation	Soundararajan, M.,Willard, F.S.,Kimple, A.J.,Turnbull, A.P.,Ball, L.J.,Schoch, G.A.,Gileadi, C.,Fedorov, O.Y.,Dowler, E.F.,Higman, V.A.,Hutsell, S.Q.,Sundstrom, M.,Doyle, D.A.,Siderovski, D.P. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105:6457-6462, 2008 Cited by PubMed: 18434541 DOI: 10.1073/pnas.0801508105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation