2ADA

ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS

Replaces:  1ADA

Summary for 2ADA

• Entry DOI: 10.2210/pdb2ada/pdb
• Descriptor: ADENOSINE DEAMINASE, ZINC ION, 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ... (4 entities in total)
• Functional Keywords: hydrolase, amino, zinc cofactor, beta/alpha barrel, transition-state inhibitor
• Biological source: Mus musculus (house mouse)
• Cellular location: Cell membrane; Peripheral membrane protein; Extracellular side (By similarity): P03958
• Total number of polymer chains: 1
• Total formula weight: 40381.24

Authors

Wilson, D.K.,Quiocho, F.A. (deposition date: 1994-12-02, release date: 1995-03-31, Last modification date: 2024-02-14)

• Primary citation: Wilson, D.K.,Rudolph, F.B.,Quiocho, F.A.; Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.; Science, 252:1278-1284, 1991; PubMed: 1925539

Experimental method

X-RAY DIFFRACTION (2.4 Å)