2ACL

Liver X-Receptor alpha Ligand Binding Domain with SB313987

Summary for 2ACL

• Entry DOI: 10.2210/pdb2acl/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, Oxysterols receptor LXR-alpha, RETINOIC ACID, ... (5 entities in total)
• Functional Keywords: nuclear hormone receptor ligand binding domain transcription factor three layered a-helix fold, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 Q9Z0Y9
• Total number of polymer chains: 8
• Total formula weight: 222167.87

Authors

Jaye, M.C.,Krawiec, J.A.,Campobasso, N.,Smallwood, A.,Qiu, C.,Lu, Q.,Kerrigan, J.J. (deposition date: 2005-07-19, release date: 2005-09-20, Last modification date: 2024-02-14)

• Primary citation: Jaye, M.C.,Krawiec, J.A.,Campobasso, N.,Smallwood, A.,Qiu, C.,Lu, Q.,Kerrigan, J.J.,De Los Frailes Alvaro, M.,Laffitte, B.,Liu, W.S.,Marino, J.P.,Meyer, C.R.,Nichols, J.A.,Parks, D.J.,Perez, P.,Sarov-Blat, L.,Seepersaud, S.D.,Steplewski, K.M.,Thompson, S.K.,Wang, P.,Watson, M.A.,Webb, C.L.,Haigh, D.,Caravella, J.A.,Macphee, C.H.,Willson, T.M.,Collins, J.L.; Discovery of substituted maleimides as liver x receptor agonists and determination of a ligand-bound crystal structure.; J.Med.Chem., 48:5419-5422, 2005; PubMed: 16107141; DOI: 10.1021/jm050532w

Experimental method

X-RAY DIFFRACTION (2.8 Å)