2A4D

Structure of the human ubiquitin-conjugating enzyme E2 variant 1 (UEV-1)

Summary for 2A4D

Entry DOI	10.2210/pdb2a4d/pdb
Descriptor	Ubiquitin-conjugating enzyme E2 variant 1 (2 entities in total)
Functional Keywords	alternative splicing; nuclear protein; ubl conjugation pathway, ubiquitin, ubiquitin- conjugating enzyme, ligase, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q13404
Total number of polymer chains	1
Total formula weight	18027.58
Authors	Walker, J.R.,Avvakumov, G.V.,Xue, S.,Newman, E.M.,Mackenzie, F.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.,Edwards, A.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2005-06-28, release date: 2005-07-12, Last modification date: 2023-08-23)
Primary citation	Sheng, Y.,Hong, J.H.,Doherty, R.,Srikumar, T.,Shloush, J.,Avvakumov, G.V.,Walker, J.R.,Xue, S.,Neculai, D.,Wan, J.W.,Kim, S.K.,Arrowsmith, C.H.,Raught, B.,Dhe-Paganon, S. A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11:329-341, 2012 Cited by PubMed: 22496338 DOI: 10.1074/mcp.O111.013706 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation