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2A2X

Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12

Summary for 2A2X
Entry DOI10.2210/pdb2a2x/pdb
Related2ANK
Related PRD IDPRD_000480
DescriptorThrombin light chain, Thrombin heavy chain, synthetic peptide, ... (5 entities in total)
Functional Keywordsblood clotting, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Total number of polymer chains3
Total formula weight35589.62
Authors
Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2005-06-23, release date: 2006-11-14, Last modification date: 2023-08-23)
Primary citationLange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W.
Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety
BIOORG.MED.CHEM.LETT., 16:2648-2653, 2006
Cited by
PubMed: 16460939
DOI: 10.1016/j.bmcl.2006.01.046
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.44 Å)
Structure validation

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