2A2K

Crystal Structure of an active site mutant, C473S, of Cdc25B Phosphatase Catalytic Domain

Summary for 2A2K

Entry DOI	10.2210/pdb2a2k/pdb
Related	1QB0 1YMK
Descriptor	M-phase inducer phosphatase 2, CHLORIDE ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	phosphatase, dual specificity, substrate trapping, active site mutant, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: P30305
Total number of polymer chains	1
Total formula weight	20832.70
Authors	Sohn, J.,Parks, J.,Buhrman, G.,Brown, P.,Kristjansdottir, K.,Safi, A.,Yang, W.,Edelsbrunner, H.,Rudolph, J. (deposition date: 2005-06-22, release date: 2006-01-03, Last modification date: 2023-08-23)
Primary citation	Sohn, J.,Parks, J.M.,Buhrman, G.,Brown, P.,Safi, A.,Edelsbrunner, H.,Yang, W.,Rudolph, J. Experimental Validation of the Docking Orientation of Cdc25 with Its Cdk2-CycA Protein Substrate. Biochemistry, 44:16563-16573, 2005 Cited by PubMed: 16342947 DOI: 10.1021/bi0516879 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation