2A1H

X-ray crystal structure of human mitochondrial branched chain aminotransferase (BCATm) complexed with gabapentin

Summary for 2A1H

Entry DOI	10.2210/pdb2a1h/pdb
Related	1EKF 1EKP 1EKV 1KT8 1KTA
Descriptor	branched chain aminotransferase, PYRIDOXAL-5'-PHOSPHATE, [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID, ... (5 entities in total)
Functional Keywords	fold type iv, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform A: Mitochondrion. Isoform B: Cytoplasm: O15382
Total number of polymer chains	2
Total formula weight	83632.84
Authors	Goto, M.,Miyahara, I.,Hirotsu, K.,Conway, M.,Yennawar, N.,Islam, M.M.,Hutson, S.M. (deposition date: 2005-06-20, release date: 2005-09-06, Last modification date: 2017-10-11)
Primary citation	Goto, M.,Miyahara, I.,Hirotsu, K.,Conway, M.,Yennawar, N.,Islam, M.M.,Hutson, S.M. Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin. J.Biol.Chem., 280:37246-37256, 2005 Cited by PubMed: 16141215 DOI: 10.1074/jbc.M506486200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation