2A0Y

Structure of human purine nucleoside phosphorylase H257D mutant

Summary for 2A0Y

Entry DOI	10.2210/pdb2a0y/pdb
Related	2A0W 2A0X
Descriptor	Purine nucleoside phosphorylase, SULFATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
Functional Keywords	purine nucleoside phosphorylase, transition state inhibitor, mutant, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32619.23
Authors	Murkin, A.S.,Shi, W.,Schramm, V.L. (deposition date: 2005-06-17, release date: 2006-06-06, Last modification date: 2023-08-23)
Primary citation	Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L. Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry, 46:5038-5049, 2007 Cited by PubMed: 17407325 DOI: 10.1021/bi700147b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation