2A0W

Structure of human purine nucleoside phosphorylase H257G mutant

Summary for 2A0W

• Entry DOI: 10.2210/pdb2a0w/pdb
• Related: 2A0X 2A0Y
• Descriptor: Purine nucleoside phosphorylase, SULFATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
• Functional Keywords: purine nucleoside phosphorylase, transition state inhibitor, mutant, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32561.20

Authors

Murkin, A.S.,Shi, W.,Schramm, V.L. (deposition date: 2005-06-17, release date: 2006-06-06, Last modification date: 2023-08-23)

• Primary citation: Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L.; Neighboring group participation in the transition state of human purine nucleoside phosphorylase.; Biochemistry, 46:5038-5049, 2007; PubMed: 17407325; DOI: 10.1021/bi700147b

Experimental method

X-RAY DIFFRACTION (2.28 Å)