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2OVR

Structure of the Skp1-Fbw7-CyclinEdegN complex

Summary for 2OVR
Entry DOI10.2210/pdb2ovr/pdb
Related2OVP 2OVQ
DescriptorS-phase kinase-associated protein 1A, F-box/WD repeat protein 7, cyclinE N-terminal degron, ... (5 entities in total)
Functional Keywordsf-box; wd40 domains; double phosphorylation, transcription-cell cycle complex, transcription/cell cycle
Biological sourceHomo sapiens (human)
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Cellular locationIsoform 1: Nucleus, nucleoplasm. Isoform 2: Cytoplasm. Isoform 4: Nucleus, nucleolus. Nucleus (By similarity): Q969H0
Total number of polymer chains3
Total formula weight69236.32
Authors
Hao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P. (deposition date: 2007-02-14, release date: 2007-04-24, Last modification date: 2011-11-16)
Primary citationHao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P.
Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases
Mol.Cell, 26:131-143, 2007
Cited by
PubMed: 17434132
DOI: 10.1016/j.molcel.2007.02.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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