289D

TARGETING THE MINOR GROOVE OF DNA: CRYSTAL STRUCTURES OF TWO COMPLEXES BETWEEN FURAN DERIVATIVES OF BERENIL AND THE DNA DODECAMER D(CGCGAATTCGCG)2

Summary for 289D

• Entry DOI: 10.2210/pdb289d/pdb
• Descriptor: DNA (5'-R(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2,5-BIS{[4-(N-CYCLOPROPYLDIAMINOMETHYL)PHENYL]}FURAN (3 entities in total)
• Functional Keywords: b-dna, double helix, complexed with drug, dna
• Total number of polymer chains: 2
• Total formula weight: 7715.29

Authors

Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S. (deposition date: 1996-10-10, release date: 1996-12-17, Last modification date: 2024-04-03)

• Primary citation: Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S.; Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.; J.Med.Chem., 39:4554-4562, 1996; PubMed: 8917643; DOI: 10.1021/jm9604484

Experimental method

X-RAY DIFFRACTION (2.2 Å)