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1ZPB

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide

Summary for 1ZPB
Entry DOI10.2210/pdb1zpb/pdb
Related1ZPC
DescriptorCoagulation factor XI, SULFATE ION, 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE, ... (4 entities in total)
Functional Keywordsfxi, inhibitor, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P03951
Total number of polymer chains1
Total formula weight27289.03
Authors
Primary citationDeng, H.,Bannister, T.D.,Jin, L.,Babine, R.E.,Quinn, J.,Nagafuji, P.,Celatka, C.A.,Lin, J.,Lazarova, T.I.,Rynkiewicz, M.J.,Bibbins, F.,Pandey, P.,Gorga, J.,Meyers, H.V.,Abdel-Meguid, S.S.,Strickler, J.E.
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine
Bioorg.Med.Chem.Lett., 16:3049-3054, 2006
Cited by
PubMed: 16524727
DOI: 10.1016/j.bmcl.2006.02.052
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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