1ZJ7

Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2

Summary for 1ZJ7

Entry DOI	10.2210/pdb1zj7/pdb
Related	1FQX 1IIQ 1LZQ 1M0B 1Z8C 1ZBG 1ZLF
Related PRD ID	PRD_000386
Descriptor	PROTEASE RETROPEPSIN, N-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide (3 entities in total)
Functional Keywords	hiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	1
Total formula weight	11523.58
Authors	Skalova, T.,Dohnalek, J.,Duskova, J.,Petrokova, H.,Hasek, J. (deposition date: 2005-04-28, release date: 2006-05-09, Last modification date: 2023-08-23)
Primary citation	Skalova, T.,Dohnalek, J.,Duskova, J.,Petrokova, H.,Hradilek, M.,Soucek, M.,Konvalinka, J.,Hasek, J. HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site J.Med.Chem., 49:5777-5784, 2006 Cited by PubMed: 16970402 DOI: 10.1021/jm0605583 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation