1Z95

Crystal Structure of the Androgen Receptor Ligand-binding Domain W741L Mutant Complex with R-bicalutamide

Summary for 1Z95

Entry DOI	10.2210/pdb1z95/pdb
Descriptor	Androgen Receptor, SULFATE ION, R-BICALUTAMIDE, ... (4 entities in total)
Functional Keywords	steroid hormones; receptors; cellular proliferation; cellular differentiation, transcription regulation, receptor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10275
Total number of polymer chains	1
Total formula weight	29173.11
Authors	Bohl, C.E.,Gao, W.,Miller, D.D.,Bell, C.E.,Dalton, J.T. (deposition date: 2005-03-31, release date: 2005-04-19, Last modification date: 2023-08-23)
Primary citation	Bohl, C.E.,Gao, W.,Miller, D.D.,Bell, C.E.,Dalton, J.T. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proc.Natl.Acad.Sci.Usa, 102:6201-6206, 2005 Cited by PubMed: 15833816 DOI: 10.1073/pnas.0500381102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation