1Z8G

Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.

Summary for 1Z8G

Entry DOI	10.2210/pdb1z8g/pdb
Related PRD ID	PRD_000307
Descriptor	Serine protease hepsin, ACE-LYS-GLN-LEU-ARG-Chloromethylketone (3 entities in total)
Functional Keywords	serine protease hepsin, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type II membrane protein: P05981
Total number of polymer chains	2
Total formula weight	41054.97
Authors	Herter, S.,Piper, D.E.,Aaron, W.,Gabriele, T.,Cutler, G.,Cao, P.,Bhatt, A.S.,Choe, Y.,Craik, C.S.,Walker, N.,Meininger, D.,Hoey, T.,Austin, R.J. (deposition date: 2005-03-30, release date: 2005-05-03, Last modification date: 2023-08-23)
Primary citation	Herter, S.,Piper, D.E.,Aaron, W.,Gabriele, T.,Cutler, G.,Cao, P.,Bhatt, A.S.,Choe, Y.,Craik, C.S.,Walker, N.,Meininger, D.,Hoey, T.,Austin, R.J. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers Biochem.J., 390:125-136, 2005 Cited by PubMed: 15839837 DOI: 10.1042/BJ20041955 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation