1YY4

Crystal structure of estrogen receptor beta complexed with 1-chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol

Summary for 1YY4

• Entry DOI: 10.2210/pdb1yy4/pdb
• Related: 1YYE
• Descriptor: Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL, ... (4 entities in total)
• Functional Keywords: estrogen receptor, estrogen receptor beta, er-beta, er, estrogen, nuclear receptor, transcription factor, agonist, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9UEV6
• Total number of polymer chains: 4
• Total formula weight: 63359.14

Authors

Mewshaw, R.E.,Edsall Jr., R.J.,Yang, C.,Manas, E.S.,Xu, Z.B.,Henderson, R.A.,Keith Jr., J.C.,Harris, H.A. (deposition date: 2005-02-23, release date: 2006-02-28, Last modification date: 2024-02-14)

• Primary citation: Mewshaw, R.E.,Edsall Jr., R.J.,Yang, C.,Manas, E.S.,Xu, Z.B.,Henderson, R.A.,Keith Jr., J.C.,Harris, H.A.; ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity; J.Med.Chem., 48:3953-3979, 2005; PubMed: 15943471; DOI: 10.1021/jm058173s

Experimental method

X-RAY DIFFRACTION (2.7 Å)