1YT7

Cathepsin K complexed with a constrained ketoamide inhibitor

Summary for 1YT7

• Entry DOI: 10.2210/pdb1yt7/pdb
• Related: 1TU6
• Descriptor: Cathepsin K, SULFATE ION, (1R)-2,2-DIMETHYL-1-({5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2-YL}METHYL)PROPYL (1S)-1-{OXO[(2-OXO-1,3-OXAZOLIDIN-3-YL)AMINO]ACETYL}PENTYLCARBAMATE, ... (4 entities in total)
• Functional Keywords: cathepsin, cysteine protease, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P43235
• Total number of polymer chains: 1
• Total formula weight: 24299.16

Authors

Barrett, D.G.,Boncek, V.M.,Catalano, J.G.,Deaton, D.N.,Hassell, A.M.,Jurgensen, C.H.,Long, S.T.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Payne, J.A.,Ray, J.A.,Samano, V.,Shewchuk, L.M.,Tavares, F.X.,Wells-Knecht, K.J.,Willard, D.H.,Wright, L.L.,Zhou, H.Q. (deposition date: 2005-02-10, release date: 2005-07-19, Last modification date: 2023-08-23)

• Primary citation: Barrett, D.G.,Boncek, V.M.,Catalano, J.G.,Deaton, D.N.,Hassell, A.M.,Jurgensen, C.H.,Long, S.T.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Payne, J.A.,Ray, J.A.,Samano, V.,Shewchuk, L.M.,Tavares, F.X.,Wells-Knecht, K.J.,Willard, D.H.,Wright, L.L.,Zhou, H.Q.; P(2)-P(3) conformationally constrained ketoamide-based inhibitors of cathepsin K.; Bioorg.Med.Chem.Lett., 15:3540-3546, 2005; PubMed: 15982880; DOI: 10.1016/j.bmcl.2005.05.062

Experimental method

X-RAY DIFFRACTION (2.3 Å)