1YRY

Crystal structure of human PNP complexed with MESG

Summary for 1YRY

Entry DOI	10.2210/pdb1yry/pdb
Descriptor	Purine nucleoside phosphorylase, SULFATE ION, 7-METHYL-6-THIO-GUANOSINE, ... (4 entities in total)
Functional Keywords	purine nucleoside phosphorylase, drug design, synchrotron, mesg, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton (By similarity): P00491
Total number of polymer chains	1
Total formula weight	32786.40
Authors	Silva, R.G.,Pereira, J.H.,Canduri, F.,Basso, L.A.,de Azevedo Jr., W.F.,Santos, D.S. (deposition date: 2005-02-05, release date: 2006-01-17, Last modification date: 2023-10-25)
Primary citation	Silva, R.G.,Pereira, J.H.,Canduri, F.,de Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine Arch.Biochem.Biophys., 442:49-58, 2005 Cited by PubMed: 16154528 DOI: 10.1016/j.abb.2005.07.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation