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1YHM

Structure of the complex of Trypanosoma cruzi farnesyl disphosphate synthase with alendronate, Isopentenyl diphosphate and mg+2

Summary for 1YHM
Entry DOI10.2210/pdb1yhm/pdb
Related1YHK 1YHL
Descriptorfarnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... (6 entities in total)
Functional Keywordsfarnesyl diphosphate synthase, alendronate, isopentenyl diphosphate, mevalonate patway, geranyl transferase, dimethylallyl transferase, fpps, transferase
Biological sourceTrypanosoma cruzi
Total number of polymer chains3
Total formula weight127766.64
Authors
Gabelli, S.B.,McLellan, J.S.,Montalvetti, A.,Oldfield, E.,Docampo, R.,Amzel, L.M. (deposition date: 2005-01-09, release date: 2005-12-20, Last modification date: 2023-11-15)
Primary citationGabelli, S.B.,McLellan, J.S.,Montalvetti, A.,Oldfield, E.,Docampo, R.,Amzel, L.M.
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.
Proteins, 62:80-88, 2005
Cited by
PubMed: 16288456
DOI: 10.1002/prot.20754
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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