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1YC3

Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles

Summary for 1YC3
Entry DOI10.2210/pdb1yc3/pdb
Related1YC1 1YC4
DescriptorHeat shock protein HSP 90-alpha, 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID (3 entities in total)
Functional Keywordscell-cycle, cancer, drug design, cell cycle
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight30178.62
Authors
Kreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X. (deposition date: 2004-12-21, release date: 2005-02-22, Last modification date: 2024-02-14)
Primary citationKreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.S.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X.J.
Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15:1475-1478, 2005
Cited by
PubMed: 15713410
DOI: 10.1016/j.bmcl.2004.12.087
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.12 Å)
Structure validation

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