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1Y9R

Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the S810L mutation responsible for a severe form of hypertension

Summary for 1Y9R
Entry DOI10.2210/pdb1y9r/pdb
DescriptorMineralocorticoid receptor, DESOXYCORTICOSTERONE (3 entities in total)
Functional Keywordsmineralocorticoid receptor; steroid receptor; nuclear recept; transcription regulation; activating mutation; hypertension, transcription, ligand binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P08235
Total number of polymer chains2
Total formula weight59949.64
Authors
Fagart, J.,Huyet, J.,Pinon, G.M.,Rochel, M.,Mayer, C.,Rafestin-Oblin, M.E. (deposition date: 2004-12-16, release date: 2005-05-24, Last modification date: 2024-02-14)
Primary citationFagart, J.,Huyet, J.,Pinon, G.M.,Rochel, M.,Mayer, C.,Rafestin-Oblin, M.E.
Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension
Nat.Struct.Mol.Biol., 12:554-555, 2005
Cited by
PubMed: 15908963
DOI: 10.1038/nsmb939
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.96 Å)
Structure validation

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