1Y57

Structure of unphosphorylated c-Src in complex with an inhibitor

Summary for 1Y57

Entry DOI	10.2210/pdb1y57/pdb
Related	1FMK 1KSW 2PTK 2SRC
Descriptor	Proto-oncogene tyrosine-protein kinase Src, SULFATE ION, 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE, ... (4 entities in total)
Functional Keywords	kinase structure, sh3, sh2, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P12931
Total number of polymer chains	1
Total formula weight	52589.48
Authors	Cowan-Jacob, S.W.,Fendrich, G.,Manley, P.W.,Jahnke, W.,Fabbro, D.,Liebetanz, J.,Meyer, T. (deposition date: 2004-12-02, release date: 2005-06-21, Last modification date: 2024-03-13)
Primary citation	Cowan-Jacob, S.W.,Fendrich, G.,Manley, P.W.,Jahnke, W.,Fabbro, D.,Liebetanz, J.,Meyer, T. The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation Structure, 13:861-871, 2005 Cited by PubMed: 15939018 DOI: 10.1016/j.str.2005.03.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation