1XXD

Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin

Summary for 1XXD

Entry DOI	10.2210/pdb1xxd/pdb
Related	1XX9 1XXF
Descriptor	Coagulation factor XI, Ecotin (3 entities in total)
Functional Keywords	fxia; catalytic domain; serine protein; ecotin, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P03951 Periplasm: P23827
Total number of polymer chains	4
Total formula weight	86124.14
Authors	Jin, L.,Pandey, P.,Babine, R.E.,Gorga, J.C.,Seidl, K.J.,Gelfand, E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E. (deposition date: 2004-11-04, release date: 2004-11-16, Last modification date: 2023-08-23)
Primary citation	Jin, L.,Pandey, P.,Babine, R.E.,Gorga, J.C.,Seidl, K.J.,Gelfand, E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E. Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J.Biol.Chem., 280:4704-4712, 2005 Cited by PubMed: 15545266 DOI: 10.1074/jbc.M411309200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation