1XW7

Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama

Summary for 1XW7

• Entry DOI: 10.2210/pdb1xw7/pdb
• Related: 1EV3
• Descriptor: Insulin, PHENOL, ZINC ION, ... (6 entities in total)
• Functional Keywords: leu-a30insulin, protein unfolding, insulin receptor, hormone-growth factor complex, hormone/growth factor
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 4
• Total formula weight: 12053.30

Authors

Wan, Z.L.,Huang, K.,Xu, B.,Chu, Y.C.,Hu, S.Q.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2004-10-29, release date: 2005-04-12, Last modification date: 2023-08-23)

• Primary citation: Wan, Z.L.,Huang, K.,Xu, B.,Hu, S.Q.,Wang, S.,Chu, Y.C.,Katsoyannis, P.G.,Weiss, M.A.; Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama; Biochemistry, 44:5000-5016, 2005; PubMed: 15794638; DOI: 10.1021/bi047585k

Experimental method

X-RAY DIFFRACTION (2.3 Å)