1XU8

The 2.8 A structure of a tumour suppressing serpin

Summary for 1XU8

Entry DOI	10.2210/pdb1xu8/pdb
Descriptor	Maspin, SULFATE ION (3 entities in total)
Functional Keywords	maspin, serpin, tumor suppressor, serpinb5, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space: P36952
Total number of polymer chains	2
Total formula weight	85579.77
Authors	Irving, J.A.,Law, R.H.,Ruzyla, K.,Bashtannyk-Puhalovich, T.A.,Kim, N.,Worrall, D.M.,Rossjohn, J.,Whisstock, J.C. (deposition date: 2004-10-25, release date: 2005-03-15, Last modification date: 2023-10-25)
Primary citation	Law, R.H.,Irving, J.A.,Buckle, A.M.,Ruzyla, K.,Buzza, M.,Bashtannyk-Puhalovich, T.A.,Beddoe, T.C.,Nguyen, K.,Worrall, D.M.,Bottomley, S.P.,Bird, P.I.,Rossjohn, J.,Whisstock, J.C. The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J.Biol.Chem., 280:22356-22364, 2005 Cited by PubMed: 15760906 DOI: 10.1074/jbc.M412043200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation