1XU2

The crystal structure of APRIL bound to BCMA

Summary for 1XU2

Entry DOI	10.2210/pdb1xu2/pdb
Related	1U5X 1U5Y 1U5Z 1XU1 1XUT
Descriptor	Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor receptor superfamily member 17, NICKEL (II) ION, ... (4 entities in total)
Functional Keywords	tnfsf, cytokine, crd, receptor, jelly-roll, cysteine-rich, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological source	Mus musculus (house mouse) More
Cellular location	Secreted (By similarity): Q9D777 Cell membrane; Single-pass type III membrane protein: Q02223
Total number of polymer chains	6
Total formula weight	62082.66
Authors	Hymowitz, S.G.,Patel, D.R.,Wallweber, H.J.A.,Runyon, S.,Yan, M.,Yin, J.,Shriver, S.K.,Gordon, N.C.,Pan, B.,Skelton, N.J.,Kelley, R.F.,Starovasnik, M.A. (deposition date: 2004-10-25, release date: 2004-11-09, Last modification date: 2023-08-23)
Primary citation	Hymowitz, S.G.,Patel, D.R.,Wallweber, H.J.A.,Runyon, S.,Yan, M.,Yin, J.,Shriver, S.K.,Gordon, N.C.,Pan, B.,Skelton, N.J.,Kelley, R.F.,Starovasnik, M.A. Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high-affinity ligand binding J.Biol.Chem., 280:7218-7227, 2005 Cited by PubMed: 15542592 DOI: 10.1074/jbc.M411714200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation