1XOE

N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with

Summary for 1XOE

• Entry DOI: 10.2210/pdb1xoe/pdb
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (6 entities in total)
• Functional Keywords: neuraminidase, pyrrolidine inhibitors, influenza, hydrolase
• Biological source: Influenza A virus
• Cellular location: Virion membrane (By similarity): P03472
• Total number of polymer chains: 1
• Total formula weight: 45562.47

Authors

Wang, G.T.,Wang, S.,Gentles, R.,Sowin, T.,Maring, C.J.,Kempf, D.J.,Kati, W.M.,Stoll, V.,Stewart, K.D.,Laver, G. (deposition date: 2004-10-06, release date: 2005-01-11, Last modification date: 2020-07-29)

• Primary citation: Wang, G.T.,Wang, S.,Gentles, R.,Sowin, T.,Maring, C.J.,Kempf, D.J.,Kati, W.M.,Stoll, V.,Stewart, K.D.,Laver, G.; Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.; Bioorg.Med.Chem.Lett., 15:125-128, 2005; PubMed: 15582424; DOI: 10.1016/j.bmcl.2004.10.022

Experimental method

X-RAY DIFFRACTION (2.2 Å)