1XMJ

Crystal structure of human deltaF508 human NBD1 domain with ATP

Summary for 1XMJ

Entry DOI	10.2210/pdb1xmj/pdb
Related	1Q3H 1R0W 1R0X 1R0Y 1R0Z 1R10 1XMI
Descriptor	Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	cftr; nbd1 domain; deltaf508; cystic fibrosis; nucleotide-binding domain 1, membrane protein, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32885.25
Authors	Lewis, H.A.,Zhao, X.,Wang, C.,Sauder, J.M.,Rooney, I.,Noland, B.W.,Lorimer, D.,Kearins, M.C.,Conners, K.,Condon, B.,Maloney, P.C.,Guggino, W.B.,Hunt, J.F.,Emtage, S.,Structural GenomiX (deposition date: 2004-10-02, release date: 2004-11-09, Last modification date: 2024-04-03)
Primary citation	Lewis, H.A.,Zhao, X.,Wang, C.,Sauder, J.M.,Rooney, I.,Noland, B.W.,Lorimer, D.,Kearins, M.C.,Conners, K.,Condon, B.,Maloney, P.C.,Guggino, W.B.,Hunt, J.F.,Emtage, S. Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure J.Biol.Chem., 280:1346-1353, 2005 Cited by PubMed: 15528182 DOI: 10.1074/jbc.M410968200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation