1XL0

Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1,3,4-oxadiazole,-benzothiazole, and-benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.

Summary for 1XL0

• Entry DOI: 10.2210/pdb1xl0/pdb
• Related: 1K06 1P4G 1P4H 1P4J 1XKX 1XL1
• Descriptor: Glycogen phosphorylase, muscle form, (1R)-1,5-anhydro-1-(5-methyl-1,3,4-oxadiazol-2-yl)-D-glucitol, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• Functional Keywords: glycogenolysis, type 2 diabetes, transferase
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 97784.56

Authors

Chrysina, E.D.,Kosmopoulou, M.N.,Tiraidis, C.,Kardakaris, R.,Bischler, N.,Leonidas, D.D.,Hadady, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Oikonomakos, N.G. (deposition date: 2004-09-30, release date: 2005-03-15, Last modification date: 2020-07-29)

• Primary citation: Chrysina, E.D.,Kosmopoulou, M.N.,Tiraidis, C.,Kardakaris, R.,Bischler, N.,Leonidas, D.D.,Hadady, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Oikonomakos, N.G.; Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site; Protein Sci., 14:873-888, 2005; PubMed: 15741340; DOI: 10.1110/ps.041216105

Experimental method

X-RAY DIFFRACTION (1.92 Å)