1XIV

Plasmodium falciparum lactate dehydrogenase complexed with 2-({4-chloro-[hydroxy(methoxy)methyl]cyclohexyl}amino)ethane-1,1,2-triol

Summary for 1XIV

Entry DOI	10.2210/pdb1xiv/pdb
Related	1u40 1u4s 1u5a 1u5c
Descriptor	L-lactate dehydrogenase, 2-({4-CHLORO-2-[HYDROXY(METHOXY)METHYL]CYCLOHEXYL}AMINO)ETHANE-1,1,2-TRIOL, GLYCEROL, ... (4 entities in total)
Functional Keywords	protein-ligand complex, oxidoreductase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	1
Total formula weight	35417.43
Authors	Conners, R.,Cameron, A.,Read, J.A.,Schambach, F.,Sessions, R.B.,Brady, R.L. (deposition date: 2004-09-22, release date: 2005-06-21, Last modification date: 2023-08-23)
Primary citation	Conners, R.,Schambach, F.,Read, J.A.,Cameron, A.,Sessions, R.B.,Vivas, L.,Easton, A.,Croft, S.L.,Brady, R.L. Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase MOL.BIOCHEM.PARASITOL., 142:137-148, 2005 Cited by PubMed: 15978953 DOI: 10.1016/j.molbiopara.2005.03.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation